Peptide confirmation by HPLC separation and detection followed by preparatory HPLC can often be time consuming, misleading and prone to error. Historic techniques such as HPLC UV detection can lead to many fractions needing to be analysed by LCMS to conclude the correct peptide mass has been synthesised and purified. Scaling from analytical flow HPLC at 1ml/min on a 4.6mm ID column to semi preparatory flow rates of 20 ml/min on a 20mm ID column has often required complicated and expensive dual HPLC systems. Here we discus an inexpensive wide flow range (0.5-20ml/min) method scouting through to semi preparatory system with mass directed and UV based purification running open access walk up software.