Human plasma proteomics studies have to date focused largely on: specific disease settings, detecting the highest number of proteins, as well as the effect of therapeutics on plasma protein expression. The majority of these studies have been adult-based, with very few studies and hence limited knowledge of the plasma proteome in neonates, infants and children. Developmental Proteomics, with a focus on age-specific differences in the human plasma proteome can be extremely useful in providing much needed knowledge, particularly as proteomics edges towards clinical applications/diagnostics. This presentation will outline the importance of unraveling age-based differences in the human plasma proteome.